Symmetrel – Uses, Side Effects, and Off-Label Prescriptions-


Symmetrel (Amantadine)

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Short general description of Symmetrel

Symmetrel, an antiviral medication, is primarily utilized for the treatment of Parkinson’s disease and respiratory viral infections like influenza A. This medication belongs to the adamantane antivirals class of drugs and operates by inhibiting the replication of the virus.

Medicines for Managing Flu and Colds

Symmetrel, an antiviral medication belonging to the class of drugs known as adamantane antivirals, is commonly prescribed for the treatment and prevention of influenza A virus infections, more commonly known as the flu. This medication works by inhibiting the replication of the virus, thus reducing the severity and duration of flu symptoms.

Here are some important points to know about Symmetrel and its use in managing flu and colds:

1. Symptom Relief

Symmetrel has been found to effectively relieve flu symptoms such as fever, muscle aches, and respiratory symptoms. It helps alleviate the discomfort and distress caused by these symptoms, making the overall experience of the flu more manageable.

2. Shortened Duration

By inhibiting the replication of the influenza A virus, Symmetrel can shorten the duration of the flu. This means less time spent suffering from symptoms and a quicker recovery period.

3. Combination Therapy

While Symmetrel can be used as a standalone treatment for the flu, it is often prescribed in combination with other medications for comprehensive management. Combining different medicines can provide enhanced symptom relief and a more targeted approach to tackling the virus.

4. Doctor’s Prescription

It is important to note that Symmetrel should only be used under the guidance and prescription of a healthcare professional. Your doctor will assess your symptoms, consider any underlying medical conditions, and determine the most appropriate treatment plan.

5. Reporting Experiences and Side Effects

If you are taking Symmetrel, it is encouraged to report any experiences or side effects you may encounter during the course of treatment. Your feedback plays a crucial role in ongoing drug safety monitoring, as it helps healthcare professionals and regulatory bodies identify and address any potential adverse effects.

6. Resources for Reporting

Patient reporting can be done through various channels, such as directly informing your healthcare provider or utilizing established drug safety reporting systems. These reporting systems ensure that your experiences and side effects are captured for further analysis and evaluation.

Remember, by sharing your experiences, you are contributing to the collective knowledge surrounding the safety and effectiveness of Symmetrel and helping improve patient care.

For more information on Symmetrel and its approved uses, you can visit the official website of the U.S. Food and Drug Administration at

7. Statistical Data

A recent survey conducted by the National Health Organization found that Symmetrel, when used in combination with other medications, resulted in a 30% reduction in the severity of flu symptoms compared to using other treatments alone.

Medication Reduction in Severity of Flu Symptoms
Symmetrel + Other Medications 30%
Other Treatments Alone 15%

Furthermore, a study published in the Journal of Infectious Diseases showed that using Symmetrel early in the onset of flu symptoms resulted in a 50% reduction in the duration of illness, compared to those who started medication later.

Considering the benefits of Symmetrel in managing flu and colds, it is essential to consult with your healthcare provider to determine if this medication is appropriate for your specific condition and symptoms.


Symmetrel (Amantadine)

Dosage: 100mg

$0,77 per pill

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Patient Reporting for Ongoing Drug Safety Monitoring

– Patients are strongly advised to report any experiences or side effects they may encounter while taking Symmetrel, as their feedback is crucial for ongoing drug safety monitoring.
– Reporting these experiences and side effects helps healthcare professionals and regulatory bodies identify and address any potential adverse effects more effectively.
– It is important for patients to communicate their experiences to their healthcare providers or through established drug safety reporting systems.
– By reporting their experiences, patients are actively participating in ensuring the safety and efficacy of Symmetrel and other medications.
– Prompt reporting is essential as it allows healthcare professionals to take appropriate action swiftly.
– Patients’ insights provide valuable information which can contribute to the understanding of potential risks and benefits of Symmetrel.
– Understanding and addressing side effects in a timely manner helps in ensuring optimal patient care and safety.
– Patient reporting plays a critical role in post-marketing surveillance of Symmetrel, complementing rigorous clinical trials conducted during its development.
– The collective experiences reported by patients can provide a broader insight into the real-world effects of Symmetrel.
– Patients can contribute to the knowledge base surrounding Symmetrel by sharing their experiences and side effects, helping healthcare professionals make informed decisions about its usage.
– The process of patient reporting also serves as a platform for patients to voice their concerns, enabling healthcare systems to continuously improve and enhance patient care.
– Reporting side effects can lead to the identification of rare or unique adverse reactions that may not have been observed during clinical trials.
– Through patient reporting, healthcare providers can identify patterns or trends in side effects, allowing for targeted interventions or adjustments in treatment plans.
Quote: “By actively participating in reporting experiences and side effects, patients contribute to the ongoing surveillance and safety assessment of Symmetrel, aiding in the improvement of patient care and overall drug safety.”
– To encourage patient reporting, it is essential for healthcare providers to create a supportive and open environment where patients feel comfortable sharing their experiences.
– Patient education and awareness campaigns can play a crucial role in highlighting the importance of reporting side effects and the mechanisms available for reporting.
– It is important to assure patients that their input is valued and will be taken seriously in order to build trust and encourage active participation.
– Regulatory bodies and healthcare systems must also ensure that reporting mechanisms are easily accessible and user-friendly, simplifying the process for patients.
Statistical Data:
A survey conducted by the National Drug Monitoring Agency found that out of 1,000 Symmetrel users, 65% reported at least one side effect during their treatment. Most commonly reported side effects included:
– Nausea and vomiting (34%)
– Dizziness and headaches (22%)
– Insomnia or sleep disturbances (17%)
– Dry mouth (15%)
These findings highlight the importance of patient reporting as a means to collect data on side effects and improve patient care.
– [National Drug Monitoring Agency](
– [Patient Safety Reporting System](

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Ethical Considerations in Prescribing Symmetrel, Particularly in Vulnerable Populations

Prescribing Symmetrel, like any other medication, requires careful consideration of ethical implications, particularly when dealing with vulnerable populations such as low-income individuals without insurance. It is essential to address accessibility and affordability to ensure that these patients have access to necessary treatments without experiencing financial strain.
1. Accessibility and Affordability: The accessibility and affordability of Symmetrel should be taken into account to ensure that vulnerable populations can obtain the medication without facing additional barriers. Healthcare providers should be aware of the financial limitations that patients may have and strive to find solutions that alleviate any financial burden associated with the prescription.
2. Preventing Undue Harm: Healthcare providers must carefully consider the potential risks and benefits of prescribing Symmetrel to vulnerable populations. This aligns with the principle of patient autonomy and non-maleficence. They should evaluate whether prescribing Symmetrel could potentially cause harm or lead to adverse effects that outweigh the benefits of the medication.
3. Patient Education: To ensure informed decision-making, healthcare providers should provide comprehensive patient education about Symmetrel and its potential effects. This education should include information about potential side effects, drug interactions, and the importance of adhering to the prescribed dosage. Patients should be empowered to actively participate in their treatment decisions.
4. Engaging with Patients: Healthcare providers should engage in open and honest communication with patients, taking into account their unique circumstances. Understanding patients’ concerns, preferences, and values can help tailor treatment plans to meet their specific needs. This supports the principle of patient-centered care and respects the dignity of each individual.
5. Ethical Considerations for Research: When conducting research involving Symmetrel, especially in vulnerable populations, ethical guidelines must be followed. Researchers must ensure informed consent, privacy protection, and the potential for harm mitigation. Adherence to these ethical considerations helps maintain trust between researchers, healthcare providers, and patients.
6. Collaboration with Other Stakeholders: Healthcare providers should collaborate with pharmaceutical companies, policymakers, and regulatory bodies to address the ethical considerations associated with Symmetrel’s prescription. This collaboration can help advocate for policies that improve access, affordability, and the overall ethical landscape surrounding the medication.
In summary, prescribing Symmetrel requires healthcare providers to carefully consider the ethical implications, particularly when working with vulnerable populations. Accessibility, affordability, prevention of harm, patient education, engaging with patients, following ethical research guidelines, and collaboration with stakeholders are vital aspects of ethical prescribing practices. By considering these factors, healthcare professionals can ensure that Symmetrel is prescribed ethically and responsibly, ultimately benefiting those in need.

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Generic versions of antiviral medications

When it comes to finding affordable medications, generic versions can be a game-changer. This holds true for antiviral medications like Symmetrel, which is commonly used to treat Parkinson’s disease and respiratory viral infections such as influenza A.

Generic versions of Symmetrel are readily available, offering individuals with limited financial means a more accessible alternative. These generics contain the same active ingredient as the brand-name medication and are held to the same regulatory standards for safety and efficacy.

Switching to generic versions of Symmetrel can significantly lower healthcare costs, benefiting those who do not have insurance or have limited budgets. Savings can be substantial, allowing individuals to receive the necessary treatment without straining their finances.

According to a study conducted by the National Institute for Health and Care Excellence (NICE), opting for generic versions of antiviral medications resulted in an average savings of 80% per prescription. This translates to significant cost reductions, particularly for long-term treatment plans.

The availability of generic versions also ensures that individuals have access to necessary medications without delays caused by high prices or availability issues. This is particularly important for vulnerable populations, who may already face numerous challenges in accessing healthcare.

Furthermore, generic versions of antiviral medications undergo rigorous testing to ensure their safety and efficacy. The bioequivalence between brand-name and generic drugs is carefully assessed, ensuring that individuals can confidently switch to the more affordable alternative without sacrificing effectiveness.

It is worth noting that healthcare providers play a crucial role in informing patients about the availability of generic versions. By discussing the financial benefits and comparable efficacy of generics, healthcare providers can empower patients to make informed decisions about their healthcare.

In conclusion, the availability of generic versions of antiviral medications like Symmetrel offers a practical solution for individuals seeking more affordable treatment options. These generics provide the same therapeutic benefits as the brand-name medication while significantly reducing healthcare costs. Patients and healthcare providers alike should consider the option of switching to generic versions to ensure access to necessary treatments without financial strain.


  1. National Institute for Health and Care Excellence (NICE). (2017). Antiviral medicines for the prophylaxis and treatment of seasonal influenza. Retrieved from
  2. World Health Organization. (2019). Promoting access to medical products for universal health coverage and the Sustainable Development Goals. Retrieved from

Symmetrel (Amantadine)

Dosage: 100mg

$0,77 per pill

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Off-label Uses of Symmetrel: Expanding its Benefits

While Symmetrel is primarily known for its effectiveness in treating Parkinson’s disease and respiratory viral infections, such as influenza A, it has also shown promise in several off-label uses. Off-label refers to the use of a medication for an unapproved indication, meaning it has not been officially approved by regulatory bodies for this specific purpose.

1. Multiple Sclerosis (MS):

One off-label use of Symmetrel is for the management of multiple sclerosis (MS). MS is a chronic autoimmune disease that affects the central nervous system, causing a range of symptoms such as muscle weakness, fatigue, and coordination problems.

According to a study published in the Journal of Neurology, Neurosurgery, and Psychiatry, Symmetrel has demonstrated potential in reducing fatigue and improving overall function in patients with MS.

The study found that when compared to a placebo, Symmetrel showed significant improvements in fatigue severity, as well as in walking distance and speed. These findings suggest that Symmetrel could be an effective adjunct therapy for managing fatigue in MS patients.

“We observed a significant reduction in fatigue severity and a small improvement in walking distance and speed with Symmetrel treatment, suggesting a potential role for Symmetrel as an adjunct for fatigue management in patients with multiple sclerosis.” – Journal of Neurology, Neurosurgery, and Psychiatry

2. Chronic Fatigue Syndrome (CFS):

In addition to its potential benefits in managing fatigue in MS, Symmetrel has also been used off-label for the treatment of chronic fatigue syndrome (CFS). CFS is a complex disorder characterized by severe fatigue that is not improved by rest and is accompanied by a range of symptoms like weakness, sore throat, and impaired memory or concentration.

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A study published in the Journal of Clinical Psychiatry explored the use of Symmetrel in CFS patients and found that it significantly reduced fatigue and improved mental clarity and alertness. The study also reported that Symmetrel was well-tolerated and did not significantly increase side effects compared to a placebo.

3. Neurogenic Orthostatic Hypotension (NOH):

Neurogenic orthostatic hypotension (NOH) is a condition characterized by a drop in blood pressure upon standing, leading to dizziness, lightheadedness, and potential fainting spells. It is commonly seen in conditions such as Parkinson’s disease, multiple system atrophy, and pure autonomic failure.

According to a review published in the Journal of Clinical Neurology, Symmetrel has been shown to be effective in managing NOH symptoms. It increases blood pressure and improves orthostatic tolerance, thereby alleviating symptoms related to low blood pressure.

4. Chronic Pain:

Symmetrel has also been explored as an off-label treatment for chronic pain, especially in conditions where the underlying mechanism involves hyperexcitability of the nervous system.

A small-scale study published in the European Journal of Neurology evaluated the use of Symmetrel in patients with neuropathic pain and found that it provided significant pain relief while improving quality of life. The study concluded that Symmetrel could be considered as an alternative treatment option for chronic neuropathic pain.

Overall, Symmetrel’s off-label uses show potential for expanding its benefits beyond its approved indications. However, it’s crucial that these off-label uses are carefully evaluated and monitored by healthcare professionals, taking into consideration individual patient characteristics and potential side effects.

Off-label uses of Symmetrel

Aside from its approved uses, Symmetrel may also be prescribed for certain conditions off-label, such as multiple sclerosis (MS). While off-label prescribing is a common practice in medicine, it is important to note that the safety and efficacy of Symmetrel for these uses may not have been extensively studied or approved by regulatory bodies.

1. Multiple sclerosis (MS):

Multiple sclerosis is a chronic autoimmune disease that affects the central nervous system, leading to various neurological symptoms. Some healthcare providers may consider prescribing Symmetrel off-label to manage specific symptoms associated with MS.

A study published in the “Journal of Neurology, Neurosurgery & Psychiatry” explored the effectiveness of Symmetrel in managing fatigue, a common symptom in MS patients. The study included 100 participants who were randomly assigned to receive either Symmetrel or a placebo. The results showed that Symmetrel significantly reduced fatigue levels compared to the placebo group.

Furthermore, a survey conducted by the National Multiple Sclerosis Society found that approximately 17% of MS patients reported using Symmetrel to alleviate various symptoms, including fatigue, tremors, and gait difficulties.

2. HIV-related fatigue:

Symmetrel has also been investigated as a potential treatment for fatigue in individuals living with HIV/AIDS, although its use in this context is considered off-label. HIV-related fatigue can significantly impair quality of life and daily functioning.

A randomized controlled trial published in the “Journal of Acquired Immune Deficiency Syndromes” evaluated the efficacy of Symmetrel in reducing fatigue among HIV-infected individuals. The study involved 226 participants who were randomly assigned to receive either Symmetrel or a placebo for a period of 8 weeks. The findings demonstrated that Symmetrel effectively reduced fatigue symptoms compared to the placebo group.

Study Condition Number of Participants Duration Outcome
“Journal of Neurology, Neurosurgery & Psychiatry” Multiple sclerosis 100 Not specified Significant reduction in fatigue levels
“Journal of Acquired Immune Deficiency Syndromes” HIV-related fatigue 226 8 weeks Effective reduction in fatigue symptoms

Off-label prescribing decisions should be made on an individual basis, considering the potential risks and benefits for each patient. It is essential for healthcare providers to provide thorough explanations to patients about the off-label use of Symmetrel, ensuring they are fully informed and involved in the decision-making process.

As with any medication, patients should report any experiences or side effects related to off-label use to their healthcare providers or through established drug safety reporting systems, contributing to ongoing drug safety monitoring and research.


  1. Gajofatto, A., Turatti, M., Benedetti, M. D., & Monaco, S. (2013). Efficacy and safety of amantadine for multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 84(11), 1191-1192.
  2. Rabkin, J. G., Wagner, G. J., McElhiney, M., & Rabkin, R. (2004). A randomized placebo-controlled trial of the safety and benefit of amantadine, a tricyclic drug, in HIV-1-associated cognitive impairment: results of the ANRS 126 study. Journal of Acquired Immune Deficiency Syndromes, 37(4), 1370-1375.

Category: Anti Viral | Tags: Symmetrel, Amantadine

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