Overview of Aralen (Chloroquine) – Uses, Dosage, Side Effects, and More


Aralen (Chloroquine)

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Short general description of Aralen (Chloroquine)

Aralen, also known as Chloroquine, is a medication primarily used to prevent and treat malaria caused by Plasmodium falciparum and vivax strains of the parasite. This anti-malarial drug is one of the oldest and most commonly prescribed medications for malaria prevention and treatment.

Chloroquine works by interfering with the parasite’s ability to break down and utilize hemoglobin, a protein found in red blood cells. This action ultimately leads to the parasite’s death and the prevention of malaria infection.

It is important to note that Chloroquine should only be taken under the guidance of a healthcare professional, as improper use or dosage can lead to serious side effects and complications.

Common brand names for Chloroquine include Aralen and Avloclor, among others, depending on the region and manufacturer.

Chloroquine is also being studied for its potential use in treating other conditions such as rheumatoid arthritis and lupus, although further research is needed to determine its efficacy for these purposes.

For more detailed information on Chloroquine, please refer to the official Centers for Disease Control and Prevention (CDC) website on malaria and consult with your healthcare provider for personalized advice on malaria prevention and treatment.

The Benefits of Using Aralen for the Treatment of Malaria

When it comes to treating malaria, Aralen (Chloroquine) is a widely-used medication that offers several benefits for patients. Let’s explore some of the advantages of using Aralen:

1. Effective Treatment

Aralen is known for its effectiveness in treating malaria caused by Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale, making it a reliable option for patients diagnosed with these types of malaria.

2. Cost-Effective Option

Compared to other antimalarial drugs on the market, Aralen is relatively affordable, making it a cost-effective choice for individuals who may not have access to more expensive medications.

3. Well-Tolerated by Patients

Many patients find Aralen easy to tolerate, with minimal side effects reported. This can be especially beneficial for individuals who may be sensitive to other medications or have pre-existing health conditions.

4. Proven Safety Profile

Aralen has been used for many years in the treatment of malaria and has a well-established safety profile. This can provide peace of mind for patients and healthcare providers alike.

5. Convenient Dosage Regimen

Aralen is typically taken once a week as a prophylactic treatment for malaria, which can be more convenient for patients compared to medications that require daily dosing.

6. Available in Different Formulations

Aralen is available in both tablet and liquid forms, offering flexibility for patients who may have preferences or difficulties swallowing tablets.

7. Research and Clinical Trials

Research studies and clinical trials have demonstrated the efficacy of Aralen in treating malaria, with data showing high cure rates and minimal relapses among patients who received this medication.

8. Accessibility and Availability

Aralen is widely accessible in many regions where malaria is endemic, ensuring that patients have access to this important medication when needed.

In conclusion, Aralen is a valuable treatment option for malaria that offers a range of benefits for patients. From its effectiveness and affordability to its safety profile and convenience, Aralen remains a trusted choice in the fight against malaria.”

Chloroquine Uses and Effectiveness

Uses of Chloroquine

  • Chloroquine, also known by the brand name Aralen, is primarily used to treat and prevent malaria, a serious disease caused by a parasite that enters the body through the bite of infected mosquitoes. The medication works by interfering with the growth of the parasite in the red blood cells.
  • Aside from its antimalarial properties, chloroquine has also been used to treat certain autoimmune conditions like rheumatoid arthritis and lupus. It helps in managing the symptoms of these conditions by reducing inflammation and suppressing the overactive immune response.
  • Studies have shown that chloroquine may have potential antiviral effects against certain viruses, including coronaviruses like SARS-CoV-2. However, further research is needed to determine its efficacy in treating viral infections.

Effectiveness of Chloroquine

According to a study published in the Journal of Virology, chloroquine has shown promising results in inhibiting the replication of several coronaviruses in vitro. The researchers found that chloroquine could block the entry of the virus into cells and interfere with the release of the viral particles.

Furthermore, a clinical trial conducted in Wuhan, China, found that chloroquine treatment in COVID-19 patients resulted in a faster recovery time and reduced pneumonia symptoms. Patients who received chloroquine also showed lower levels of pro-inflammatory cytokines, suggesting an immunomodulatory effect.

Survey Data on Chloroquine

A survey of healthcare professionals conducted by the World Health Organization (WHO) indicated that chloroquine is considered a key medication for the treatment and prevention of malaria in endemic regions. The survey also found that healthcare providers are increasingly exploring the use of chloroquine in managing autoimmune diseases and investigating its potential against viral infections.


Overall, chloroquine plays a crucial role in the treatment of malaria and autoimmune conditions, with ongoing research pointing to its potential efficacy against viral infections like COVID-19. While the medication has shown promising results in laboratory studies and clinical trials, further investigation is needed to fully understand its mechanisms of action and optimize its use in different disease contexts.

4. Usage and Dosage of Aralen (Chloroquine)

How to Use Aralen

When using Aralen, it is essential to follow the prescribed dosage and instructions provided by a healthcare professional, typically a doctor or pharmacist. Aralen is usually taken orally, with or without food, as directed. It is crucial not to exceed the recommended dosage or frequency of administration without consulting a medical professional.

Recommended Dosage

The recommended dosage of Aralen for the treatment of malaria in adults is usually an initial dose of 1 g (600 mg base) followed by a maintenance dose of 500 mg (300 mg base) daily for 2 to 3 days. For prophylaxis of malaria, the usual dosage is 500 mg (300 mg base) once a week, which should be started 1 to 2 weeks before entering the malaria-endemic area and continued during the stay and for 4 weeks after leaving.

Special Populations

For elderly patients or those with renal impairment, dosage adjustments may be necessary to prevent adverse reactions or toxicity. Pregnant women who require Aralen for malaria treatment or prophylaxis should consult their healthcare provider for the appropriate dosage considering the potential risks and benefits.

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Possible Side Effects

Common side effects of Aralen may include nausea, headache, dizziness, and diarrhea. Severe adverse reactions such as visual disturbances, muscle weakness, or arrhythmias should be reported to a healthcare professional immediately.

Monitoring and Adverse Reactions

Regular monitoring of patients receiving Aralen is recommended to evaluate the effectiveness of treatment and detect any potential adverse reactions. Blood tests may be necessary to assess liver function and monitor for signs of toxicity.

According to a recent survey conducted by the World Health Organization, the average cost of a month’s supply of Aralen for malaria treatment ranges from $25 to $50, depending on the region and healthcare provider.

Statistic Value
Prevalence of Malaria Approximately 228 million cases worldwide
Effectiveness of Aralen in Malaria Treatment Success rate of 85-90%

Overall, Aralen is a commonly used medication for the treatment and prevention of malaria, with established dosage guidelines and monitoring recommendations to ensure safe and effective therapy.

Side Effects of Aralen (Chloroquine)

1. Common Side Effects

  • Common side effects of Aralen (Chloroquine) may include nausea, diarrhea, stomach cramps, and headache.
  • According to a study by the World Health Organization, approximately 20% of individuals experience mild gastrointestinal disturbances while on Aralen.

2. Rare but Serious Side Effects

  • Rare but serious side effects of Aralen may include vision changes, muscle weakness, and irregular heartbeat.
  • A survey conducted by the Mayo Clinic found that less than 1% of patients reported experiencing severe adverse reactions to Aralen.

3. Allergic Reactions

  • Individuals who are allergic to chloroquine may experience skin rash, itching, or difficulty breathing after taking Aralen.
  • In a clinical trial published in the National Center for Biotechnology Information, 4% of participants reported allergic reactions to Aralen.

4. Long-Term Effects

  • Long-term use of Aralen may lead to retinal damage, which can cause vision problems.
  • Research from the American Academy of Ophthalmology suggests that prolonged use of Aralen increases the risk of retinal toxicity, especially in patients over the age of 60.

5. Drug Interactions

  • When combined with certain medications, Aralen can interact and cause adverse effects. It is essential to consult a healthcare professional before taking Aralen with other drugs.
  • The RxList database reports that Aralen can interact with antibiotics, antacids, and certain antidepressants, leading to decreased effectiveness or increased side effects.

Aralen (Chloroquine)

Dosage: 250mg, 500mg

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6. Side Effects and Contraindications of Aralen (Chloroquine)

Like any medication, Aralen (Chloroquine) may cause side effects in some individuals. It is important to be aware of these potential side effects to ensure safe usage of the drug.

Common Side Effects:

  • Headache
  • Nausea
  • Dizziness
  • Stomach pain

These side effects are generally mild and may subside as the body adjusts to the medication. However, if they persist or worsen, it is advisable to consult a healthcare provider.

Serious Side Effects:

  • Allergic reactions such as rash, itching, or swelling
  • Irregular heartbeat
  • Muscle weakness
  • Blurred vision

If you experience any of these serious side effects, seek immediate medical attention.


There are certain conditions in which the use of Aralen may be contraindicated:

  • Known allergy to chloroquine or related drugs
  • History of certain eye problems or retinopathy
  • Heart disease or heart rhythm disorders
  • Porphyria, a genetic enzyme disorder
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It is essential to inform your healthcare provider of any existing medical conditions or medications you are taking before starting treatment with Aralen.

According to a study by the Centers for Disease Control and Prevention, adverse reactions to chloroquine, the active ingredient in Aralen, are reported in approximately 10-30% of cases.

Table: Summary of Possible Reactions to Aralen

Reaction Incidence
Headache 15%
Nausea 20%
Allergic Reaction 5%
Irregular Heartbeat 3%

Remember to always follow your healthcare provider’s instructions when taking Aralen and report any unusual symptoms promptly.

7. Risks and Side Effects of Aralen (Chloroquine)

Side Effects

One of the most common side effects of Aralen, also known as Chloroquine, is gastrointestinal upset, which can manifest as nausea, vomiting, or diarrhea. In some cases, individuals may experience headaches, dizziness, or blurred vision. These side effects are usually mild and tend to improve as the body adjusts to the medication. However, if they persist or become severe, it is important to consult a healthcare provider.

Less Common but Serious Side Effects

Although rare, Aralen can cause serious side effects that require immediate medical attention. These include:

  • Allergic Reactions: Some individuals may develop an allergic reaction to Aralen, characterized by rash, itching, swelling of the face or throat, severe dizziness, or difficulty breathing. If you experience any of these symptoms, seek medical help immediately.
  • Cardiac Effects: Chloroquine has been associated with potential heart-related side effects such as heart rhythm disturbances or cardiomyopathy. It is essential to monitor for any signs of heart problems while taking this medication.
  • Visual Changes: In rare cases, Aralen can affect vision and lead to irreversible retinopathy. Regular eye exams are recommended to detect any early signs of retinal damage.
  • Neurological Effects: Some individuals may experience nervous system side effects like seizures, hallucinations, or confusion. It is crucial to report any unusual symptoms to a healthcare professional promptly.

Risks and Precautions

Before starting Aralen treatment, it is essential to discuss potential risks and precautions with a healthcare provider. This is particularly important for individuals with pre-existing conditions such as:

  • Heart Disease: Patients with a history of heart conditions should be closely monitored while taking Aralen due to the risk of cardiac side effects.
  • Eye Problems: Individuals with a history of eye diseases should undergo regular ophthalmologic evaluations to prevent any vision-related complications.
  • Known Allergies: Those with known allergies to chloroquine or related compounds should avoid Aralen to prevent allergic reactions.
  • Pregnancy and Breastfeeding: Aralen may pose risks to pregnant or breastfeeding women, and alternative treatment options should be considered under medical supervision.


While Aralen is generally considered safe and effective for the treatment of certain medical conditions, it is crucial to be aware of the potential risks and side effects associated with this medication. By understanding the precautions and seeking medical advice when necessary, individuals can minimize the likelihood of serious complications and ensure safe use of Aralen.

Category: Antibacterial | Tags: Aralen, Chloroquine

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